There is a need for a systematic approach to reduce the consequences of the coronavirus disease-2019 (Covid-19) outbreak. The most effective way to prevent this disease is to cut off the virus transmission chain. This study aimed to propose a systematic model for the management of the Covid-19 crisis based on the bow-tie analysis model and the concept of Layers of Protection Analysis from the perspective of safety engineering. In this model, five layers of defense have been introduced to reduce the patient's referral to the hospitals and effectively manage the disease transmission chain. In addition to maintaining the health of citizens, the implementation of this model will improve the health of healthcare workers by reducing the burden of patient admission to hospitals