Volume 1, Issue 4 (Winter 2015)                   johe 2015, 1(4): 19-29 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Jalali M, Zare M J, Brahmi A, Barijani N, Mahjub H. Analysis of Endogenous Alkanes and Aldehydes in the Exhaled Breath of Workers Exposed to Silica Containing Dust . johe. 2015; 1 (4) :19-29
URL: http://johe.umsha.ac.ir/article-1-68-en.html
hamadan university of medical science , bahrami@umsha.ac.ir
Abstract:   (4812 Views)

 Background & Objectives : Silica is one of the most air pollutant in workplaces which long-term occupational exposure to silica is associated with an increased risk for respiratory diseases such as silicosis. Silicosis is an oxidative stress related disease and can lead to the development of lung cancer. This study aims to analysis of endogenous alkanes and aldehydes in the exhaled breath of workers exposed to silica containing dusts.

 Methods: In this study, the exhaled breath of 20 workers exposed to silica containing dust (case group), 20 healthy non-smokers and 25 healthy smokers (control group) were analyzed. The breath samples using 3-liter Tedlar bags were collected. The volatile organic compounds (VOCs) were extracted with solid phase micro-extraction (SPME) and analyzed using gas chromatography-mass spectrometry (GC- MS).

 Result: Totally, thirty nine VOCs were found in all breath samples (at least once). Aldehydes and alkanes such as acetaldehyde, hexanal, nonanal, decane, pentadecane, 2-methle propane, 3-methyle pentane and octane were detected in the exhaled breath subjects. Among the these compounds, mean peak area of acetaldehyde, hexanal, nonanal, decane and pentadecane were higher in the exhaled breath of an case group than control groups (Pvalue<0.05) .

 Conclusions : The use of exhaled breath analysis as well as new media in the occupational toxicology and exposure biomarker assessment studies. It seems that acetaldehyde, hexanal, nonanal, decane and pentadecane can be considered as useful breath biomarkers for exposure assessment of silica containing dust. However, additional studies are needed to confirm thes results.

Full-Text [PDF 327 kb]   (1827 Downloads)    
Type of Study: Research Article | Subject: Toxicology

Add your comments about this article : Your username or Email:

Send email to the article author

© 2020 All Rights Reserved | Journal of Occupational Hygiene Engineering

Designed & Developed by : Yektaweb